Treating pulmonary embolism: How safe and effective are new devices?

Pulmonary embolism (PE), a blood clot lodged in one of the pulmonary arteries in the lungs, is the third leading cause of cardiovascular-related death in the United States. While most patients are treated with anticoagulants (commonly known as blood thinners), the use of novel interventional devices that remove or dissolve clots in the lungs has significantly increased in recent years. Yet, there is little data—particularly, as it pertains to the treatment of patients with "intermediate-risk PE"—that suggests these approaches are more safe and effective than the use of anticoagulation alone, according to a new scientific statement from the American Heart Association (AHA) that was led by Penn Medicine.